BPC 157

Product Specifications

• CAS: 137525-51-0
• Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
• Molecular Formula: C₆₂H₉₈N₁₆O₂₂
• Molecular Mass: 1419.55 Da
• Purity: 99%+ (verified by HPLC)
• Appearance: White to off-white lyophilized powder

Storage

BPC-157 vials must be stored in a cool, dry place away from direct sunlight. Unreconstituted BPC 157 peptide should be kept at -20°C for long-term storage or 2-8°C for short-term storage (up to 3 months). Once reconstituted with bacteriostatic water, BPC-157 should be refrigerated at 2-8°C and used within 28-30 days for optimal stability. Do not freeze reconstituted solutions. Always follow proper aseptic technique and storage guidelines to maintain product integrity for research applications.

Solubility

BPC-157 is freely soluble in bacteriostatic water and sterile saline. Recommended reconstitution concentration is 0.5-2 mg/mL. Gently swirl the vial after adding solvent. Do not vortex or shake vigorously, as this may damage the peptide structure. BPC 157 is notably stable in acidic aqueous conditions, including simulated gastric fluid, which underlies research into oral BPC-157 administration.

Intended Use

BPC-157 is intended for research purposes only and is not approved for human use.

What Is BPC 157? Mechanism of Action, VEGF, Weight Loss & Muscle Growth

• BPC-157 is a synthetic 15-amino acid peptide derived from a protective protein found naturally in human gastric juice. Research focuses on its ability to activate multiple repair pathways at once, rather than targeting a single receptor,making it one of the most broadly studied regenerative peptides in preclinical science.
• At the molecular level, BPC-157 upregulates VEGF to stimulate new blood vessel growth (angiogenesis) at injury sites, delivering oxygen and nutrients to damaged tissue. It also activates the FAK-paxillin pathway and boosts nitric oxide via eNOS, driving cell migration toward wounds. This multi-pathway activity is what underpins BPC-157 research for muscle growth, fat metabolism, and tissue repair.

BPC 157 Benefits for Wound Healing, Tendon Repair, and Muscle Growth

• BPC-157 benefits for musculoskeletal repair are among the most well-documented in preclinical research. Tendon transection studies show treated subjects recovered up to 87% of normal tensile strength, with measurably higher collagen density and organisation than untreated controls. Similar results have been seen in ligament, muscle tear, and bone fracture models, where BPC 157 accelerated healing, and promoted earlier callus formation.
• BPC-157 gut repair research is equally well supported. The peptide heals gastric ulcers caused by alcohol, NSAIDs, and corticosteroids in animal models, and reverses intestinal permeability (leaky gut) by restoring tight junction proteins. BPC-157 benefits for women and men are mechanistically equivalent across all studied models, with side effects remaining consistently minimal in both.

BPC-157 and TB-500: Mechanisms Compared and Combined Use in Research

• BPC-157 and TB-500 are two of the most compared peptides in regenerative research. BPC-157 works primarily through blood vessel growth, nitric oxide signalling, and gut protection — making it especially relevant to tendon, ligament, and gastrointestinal repair. TB-500 works through actin regulation and cell migration, driving stem cells and repair cells toward injury sites, with particularly strong activity in systemic and cardiac tissue.
• BPC 157 and TB-500 are considered mechanistically complementary rather than redundant. TB 500 vs BPC 157 in head-to-head wound models shows additive effects when both are present, suggesting the two peptides engage different phases of the repair cascade: BPC-157 initiating vascular remodelling and mucosal protection, TB-500 accelerating cell migration and anti-inflammatory resolution.

BPC 157 Dosage for Research

The BPC 157 dosage used in preclinical research varies by study design, animal model, and administration route. Common dosing protocols in the published literature include:

• Subcutaneous injection: 1-10 mcg/kg body weight, the most common route for systemic and musculoskeletal research. This translates to approximately 90-900 mcg for a 90 kg research subject when calculating BPC-157 dosage per body weight. For a 200 lb (90 kg) research model, a mid-range BPC 157 dosage of 2.5-5 mcg/kg is most frequently represented in the published literature.
• Intraperitoneal injection: 10-100 mcg/kg body weight, used in gastrointestinal, inflammatory, and systemic studies where broader distribution is needed.
• Oral administration: 1-100 mcg/kg in water or saline. Oral BPC-157 exploits the peptide's notable stability in gastric acid, and is used specifically in GI-targeted protocols. Research into oral BPC 157 shows comparable efficacy to injection for intestinal permeability and ulcer healing endpoints.
• Topical / local injection: Applied directly to the injury site in tendon, ligament, and wound models. BPC 157 injection near the lesion consistently outperforms systemic routes in localised tissue repair studies.

BPC 157 dosage frequency in most research protocols is once daily, with study durations ranging from 7 to 30 days depending on the injury model and endpoint. A peptide calculator can help scale published mcg/kg doses to a given research subject weight

BPC-157 and TB-500 Dosage in Combined Research Protocols

When BPC 157 and TB-500 are studied together, each peptide is typically dosed independently at its own published range rather than at a reduced combined dose. BPC 157 TB 500 dosage protocols in the literature use BPC-157 at 2-10 mcg/kg and TB-500 at 1-6 mg/kg concurrently or in alternating schedules.

Research Protocol Notes

This product is intended for research purposes only and should not be used for human consumption. It is strictly designated for laboratory and scientific use by qualified professionals. Common research applications include:

• In vitro cellular assays and cell culture studies
• Receptor binding profiling and signaling pathway analysis
• Analytical reference standards for High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS)
• Approved in vivo animal modeling to investigate physiological mechanisms and metabolic responses