Sermorelin Peptide

Product Specifications

• CAS: 86168-78-7
• Also Known As: Sermorelin Acetate, GHRH(1-29)-NH₂, GRF(1-29)
• Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
• Molecular Formula: C₁₄₉H₂₄₆N₄₄O₄₂S
• Molecular Mass: 3357.9 Da
• Purity: 99%+ (verified by HPLC)
• Appearance: White to off-white lyophilized powder

Storage

Sermorelin vials must be stored in a cool, dry place away from direct sunlight. Unreconstituted sermorelin peptide should be kept at -20°C for long-term storage or 2-8°C for short-term use. Does sermorelin need to be refrigerated? Once reconstituted with bacteriostatic water, sermorelin must be stored at 2-8°C and used within 28-30 days. Do not freeze reconstituted solutions. Always follow proper aseptic technique and storage guidelines to maintain product integrity for research applications.

Solubility

Sermorelin is freely soluble in bacteriostatic water and sterile saline. Gently swirl the vial after adding solvent. Do not vortex or shake vigorously.

Intended Use

Sermorelin is intended for research purposes only and is not approved for human use.

What Is Sermorelin? GHRH Receptor Activation and Pulsatile GH Release

• Sermorelin is a 29-amino acid synthetic peptide corresponding to the biologically active N-terminal fragment of endogenous GHRH. It binds to and activates the GHRH receptor (GHRHR) on pituitary somatotrophs with the same receptor affinity as full-length GHRH, triggering the synthesis and pulsatile release of growth hormone in a pattern that closely mirrors the body's natural secretory rhythm.
• What does sermorelin do at the cellular level: GHRHR activation by sermorelin increases intracellular cAMP via adenylyl cyclase signalling, stimulating both the immediate release of stored GH from secretory granules and the transcription of the GH gene for sustained production. Each administration produces a discrete, short-duration GH pulse reflecting sermorelin's 10-20 minute plasma half-life.
• Is sermorelin safe? Preclinical studies across multiple animal models show a well-tolerated profile at research doses, with no significant off-target receptor activation outside the GHRH signalling pathway. The peptide is highly specific for the GHRHR, which limits systemic off-target effects compared to compounds that activate multiple receptor classes.

Sermorelin Benefits for Muscle Growth, Body Composition, and Weight Loss

• Sermorelin peptide benefits for body composition operate through the GH/IGF-1 axis: sermorelin-stimulated GH pulses drive hepatic IGF-1 production, which in turn activates anabolic signalling in skeletal muscle (PI3K/Akt/mTOR pathway) and promotes lipolysis in adipose tissue. Research demonstrates that pulsatile GH stimulation supports lean mass preservation and fat reduction in animal models.
• Sermorelin dosage for muscle growth in animal research is linked to the amplitude and frequency of GH pulses generated. Studies show that more frequent administration can increase total daily GH output and correspondingly elevate circulating IGF-1, the primary downstream mediator of sermorelin's anabolic effects on skeletal muscle and bone.
• Sermorelin for weight loss and sermorelin weight loss research in preclinical models identifies GH-driven lipolysis as the primary mechanism, with elevated GH promoting free fatty acid mobilisation from adipocytes and shifting substrate utilisation toward fat oxidation. Sermorelin before and after body composition studies in animal models show measurable reductions in fat mass over sustained research periods of 4-12 weeks.

Sermorelin vs Ipamorelin, CJC 1295, and Tesamorelin

• Sermorelin vs ipamorelin: sermorelin acts on the GHRH receptor (GHRHR) via the cAMP pathway, while ipamorelin acts on the GHS-R (ghrelin receptor) via the phospholipase C/calcium pathway. Both stimulate GH release through different receptor targets. Combined sermorelin and ipamorelin administration produces a synergistic GH pulse greater than either compound alone, as the two pathways converge on GH secretion from pituitary somatotrophs.
• Sermorelin vs CJC 1295: sermorelin matches the native GHRH(1-29) amino acid sequence without the four stabilising substitutions found in CJC 1295 (Modified GRF 1-29). CJC 1295 has a longer active half-life (approximately 30 minutes vs 10-20 minutes for sermorelin) due to greater DPP-4 resistance, producing a somewhat more sustained GH pulse per administration. Both activate the same GHRHR receptor.
• Tesamorelin vs sermorelin: tesamorelin is a synthetic GHRH analogue that includes the full 44-amino acid GHRH sequence with a trans-3-hexenoic acid modification at the N-terminus that confers greater stability. Tesamorelin has a longer half-life than sermorelin and has been studied for its effects on visceral adipose tissue reduction in animal models of metabolic dysfunction, representing a distinct research profile from sermorelin's shorter-duration GH pulse approach.

Sermorelin Dosage for Research

Sermorelin dosage used in preclinical research varies by study design, animal model, and administration route. Its short plasma half-life of 10–20 minutes requires more frequent administration than longer-acting GHRH analogues. Common dosing protocols in published literature include:

• Subcutaneous injection: 1–10 mcg/kg body weight, once to twice daily. The most common route in published research, typically timed before rest or fasted states to align with natural GH secretion windows.
• Intraperitoneal injection: Used in rodent studies for consistent systemic delivery in pharmacokinetic and GH pulse characterisation protocols.
• Intravenous injection: Used in some pharmacokinetic studies to establish bioavailability and half-life benchmarks, particularly when comparing sermorelin directly against CJC-1295 and tesamorelin.

Sermorelin dosage frequency in research protocols is typically once or twice daily, with study durations of 4–12 weeks required for statistically significant body composition changes. A peptide calculator can help scale published mcg/kg doses to a given research subject weight.

Research Protocol Notes

This product is intended for research purposes only and should not be used for human consumption. It is strictly designated for laboratory and scientific use by qualified professionals. Common research applications include:

• In vitro cellular assays and cell culture studies
• Receptor binding profiling and signaling pathway analysis
• Analytical reference standards for High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS)
• Approved in vivo animal modeling to investigate physiological mechanisms and metabolic responses